Sodium selective ion channel formation in living cell membranes by polyamidoamine dendrimer
نویسندگان
چکیده
منابع مشابه
Molecular aspects of channel formation and ion transport through membranes
A summary Is presented of theoretlcal studles almlng at a better understandlng of the coupling propertles of polypeptlde a-helical segments. and of their aggregation into bundles of various sizes capable of encloslng channels apt to transport Ions through biological membranes. The molecular aspects are stressed. INTRODUCTION Blologlcal membranes surround the cells and thelr varlous compartments...
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15 صفحه اولPolyamidoamine dendrimer impairs mitochondrial oxidation in brain tissue
BACKGROUND The potential nanocarrier polyamidoamine (PAMAM) generation 5 (G5-NH(2)) dendrimer has been shown to evoke lasting neuronal depolarization and cell death in a concentration-dependent manner. In this study we explored the early progression of G5-NH(2) action in brain tissue on neuronal and astroglial cells. RESULTS In order to describe early mechanisms of G5-NH(2) dendrimer action i...
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Dendrimers have emerged as promising multifunctional nanomaterials for drug delivery due to their well-defined size and tailorability. We compare two schemes to obtain methylprednisolone (MP)-polyamidoamine dendrimer (PAMAM-G4-OH) conjugate. Glutaric acid (GA) was used as a spacer to facilitate the conjugation. In scheme A, PAMAM-G4-OH was first coupled to GA and then further conjugated with MP...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Biomembranes
سال: 2013
ISSN: 0005-2736
DOI: 10.1016/j.bbamem.2013.04.004